Sudden death syndrome (SDS) refers to the unexpected occurrence of death from natural causes within one hour after symptoms first appear, according to the World Health Organization (WHO).
SDS is often confused with sudden cardiac death (SCD), also known as sudden cardiac arrest (SCA), with the terms sometimes being used interchangeably.
SCD is specifically the sudden failure of heart function leading to death within an hour of the onset of any heart-related symptoms.
Although SDS can result from various medical conditions, SCD is a frequent cause, initiating a lethal sequence of events within the body.
A comprehensive study from 2022 revealed that cardiovascular issues are responsible for up to 73% of sudden, unexpected deaths, compared to other causes like intracerebral hemorrhage, asthma, and epilepsy.
Symptoms of SDS can vary widely because it encompasses multiple diseases and conditions, rather than being a disease itself. The symptoms depend largely on the underlying cause.
There may be minor signs of different conditions that could lead to SDS. For example, symptoms of a cerebral aneurysm might be mistaken for simple headaches or neck stiffness.
Causes of SDS
Various known and unknown bodily mechanisms can lead to SDS, with cardiovascular disease being a primary factor, as noted by Medical News Today.
Sudden arrhythmic death syndrome (SADS) and coronary artery disease are among the leading causes. Coronary artery disease alone is linked to up to 80% of SDS cases in individuals with sickle cell disease. Research involving a large cohort found that 53% of examined SCD instances were attributed to SADS.
Risk Factors for SDS
Given the wide range of diseases that can cause SDS, the risk factors are diverse.
Since SCD is a predominant cause of SDS, its risk factors include excessive alcohol use, smoking, lack of physical activity, obesity, high blood pressure, and a family history of SCD, among others.
Prevention Strategies
Managing chronic diseases and adopting healthier lifestyle choices can help prevent SDS.
For those at elevated risk of cardiovascular issues, medical treatments combined with lifestyle modifications can significantly reduce the likelihood of cardiovascular incidents.